IGCSE Biology · Topic 14 Part A · 2026 Exam

Coordination: Nervous System & Senses

The CNS and peripheral nervous system; three neurone types; the five-component reflex arc; Extended neurone structure, synaptic transmission, myelin; eye structures and functions; Extended pupil reflex with iris muscles, accommodation mechanism, and rods vs cones.

Topics 14.1–14.2 Part A of 2 Core Extended Papers 1–4
My Study Progress — Topic 14A
0
Mastered
0
Reviewing
2
Not Started
Topic 14.1

The Nervous System

CORE EXTENDED
Mastery:
○ Not Started
◑ Reviewing
✓ Mastered

Overview of the Nervous System

The nervous system allows animals to detect stimuli, process information, and produce coordinated responses. It works alongside the hormonal system but is faster and more precise.

DivisionComponentsFunction
Central Nervous System (CNS) Brain + spinal cord Receives, processes, and coordinates information; initiates responses
Peripheral Nervous System (PNS) All nerves outside the CNS (sensory and motor nerves) Carries nerve impulses between CNS and rest of body

Neurones — Types and Functions

Neurone typeFunctionLocation
Sensory neurone Carries impulses from receptors (sense organs) to the CNS Peripheral nervous system
Motor neurone Carries impulses from the CNS to effectors (muscles or glands) Peripheral nervous system
Relay neurone
(interneurone)
Connects sensory and motor neurones within the CNS; processes information Brain and spinal cord (CNS only)

Structure of a Motor Neurone — Extended

StructureFunction
Cell bodyContains nucleus and most organelles; metabolic centre of the cell
DendritesShort, branching extensions from the cell body that receive impulses from other neurones
AxonLong fibre that carries the impulse away from the cell body toward the effector
Myelin sheathFatty insulating layer around the axon (formed by Schwann cells); speeds up impulse transmission by forcing the impulse to ‘jump’ between gaps (nodes of Ranvier)
Nodes of RanvierGaps in the myelin sheath; impulse jumps from node to node (saltatory conduction) — increases speed of transmission
Synaptic knobsTerminal endings of the axon that release neurotransmitters at synapses

Reflex Arc

Definition of a reflex action

A reflex action is a rapid, automatic, involuntary response to a stimulus. Reflex actions are not controlled by conscious thought — they bypass the brain’s decision-making centres (cerebral cortex) and are processed in the spinal cord (or brainstem for cranial reflexes). This makes them faster than voluntary responses.

The reflex arc — pathway in order

Receptor → Sensory neurone → Relay neurone (in CNS) → Motor neurone → Effector

Example — hot object: Pain receptor in skin detects heat → sensory neurone carries impulse to spinal cord → relay neurone in spinal cord → motor neurone carries impulse to arm muscle → muscle contracts (withdraws hand). The brain receives the signal later but is not required for the initial response.

Why reflexes are important

Speed protects the body from damage. Because reflexes bypass the conscious brain, the response occurs in milliseconds — before the brain has even processed the pain. This minimises tissue damage in dangerous situations.

Examples of reflex actions

Withdrawing hand from heat; blinking when an object approaches the eye; pupil constriction in bright light; knee-jerk reflex; salivation in response to food; coughing and sneezing.

Synaptic Transmission — Extended

How a synapse works

A synapse is a junction between two neurones (or between a neurone and an effector). There is a tiny gap — the synaptic cleft — that an electrical impulse cannot cross directly. Instead:

1. An impulse arrives at the synaptic knob (pre-synaptic membrane).

2. Vesicles containing neurotransmitter molecules fuse with the pre-synaptic membrane and release the neurotransmitter into the synaptic cleft.

3. Neurotransmitter diffuses across the synaptic cleft.

4. Neurotransmitter binds to specific receptors on the post-synaptic membrane — if enough molecules bind, a new impulse is generated in the next neurone.

5. Neurotransmitter is then broken down by enzymes (or reabsorbed) so the synapse can reset and receive the next impulse.

Why synapses are important (not just junctions)

1. One-way transmission: Neurotransmitter is only released from the pre-synaptic side — impulses cannot travel backwards. This ensures information flows in one direction only.

2. Integration: A relay neurone may receive inputs from many neurones simultaneously. Only if enough neurotransmitter accumulates will a new impulse be generated — allowing the CNS to filter and process signals.

MCQ · Topic 14.1Core

A person touches a hot surface and immediately withdraws their hand before feeling pain. Which pathway correctly describes the reflex arc involved?

  • A. Receptor → motor neurone → brain → sensory neurone → effector
  • B. Effector → relay neurone → sensory neurone → motor neurone → receptor
  • C. Receptor → sensory neurone → relay neurone → motor neurone → effector
  • D. Receptor → relay neurone → brain → motor neurone → effector
Answer: C. The reflex arc always follows: receptor → sensory neurone → relay neurone (in spinal cord) → motor neurone → effector. The brain is NOT part of the reflex arc — this is what makes reflexes rapid. The signal reaches the brain later (explaining why you feel pain after you have already withdrawn your hand).
Topic 14.2

Sense Organs

CORE EXTENDED
Mastery:
○ Not Started
◑ Reviewing
✓ Mastered

Receptors and Sense Organs

A receptor is a cell (or group of cells) that detects a specific stimulus and converts it into a nerve impulse. Sense organs contain many receptors grouped together.

Sense organStimulus detectedReceptor type
EyeLightPhotoreceptors (rods and cones in the retina)
EarSound; balance/head positionHair cells in cochlea (sound); hair cells in semicircular canals (balance)
NoseChemicals (smell)Olfactory receptors
TongueChemicals (taste)Taste receptors in taste buds
SkinTouch, pressure, pain, temperatureVarious mechanoreceptors and thermoreceptors

Structure of the Eye

StructureFunction
CorneaTransparent outer layer; refracts (bends) most of the light entering the eye — provides most of the eye’s focusing power
IrisColoured ring of muscle around the pupil; controls the size of the pupil (amount of light entering)
PupilHole in the centre of the iris; size controlled by the iris muscles
LensTransparent, flexible structure that fine-tunes focusing by changing shape (accommodation)
Ciliary musclesRing of muscle that controls the shape of the lens for accommodation
Suspensory ligamentsFibres connecting ciliary muscles to lens; transmit tension changes to alter lens shape
RetinaLight-sensitive layer at the back of the eye containing rods (dim light, black/white) and cones (bright light, colour)
Fovea (yellow spot)Region of densest cone concentration; highest visual acuity; where sharp colour vision occurs
Blind spotWhere the optic nerve exits the eye; no photoreceptors; cannot detect light
Optic nerveBundle of nerve fibres carrying impulses from retina to the brain
ScleraWhite, tough outer coat; protects the eye and maintains its shape
ChoroidPigmented, blood-vessel-rich layer between sclera and retina; absorbs stray light and nourishes the retina
Vitreous humourJelly-like substance filling the main chamber of the eye; maintains shape
Aqueous humourWatery fluid between cornea and lens; nourishes cornea and lens; maintains pressure

Pupil Reflex — Extended

ConditionIris responsePupil sizePurpose
Bright light Circular (constrictor) muscles of iris contract; radial muscles relax Pupil constricts (smaller) Reduces light entering the eye — protects the retina from damage
Dim light Radial (dilator) muscles of iris contract; circular muscles relax Pupil dilates (larger) Allows more light to enter — maximises vision in low light
Circular vs radial muscles — memory tip

Think of the iris as having two sets of muscles arranged like a target:

Circular (constrictor) muscles run in rings around the pupil — when they contract, the ring tightens, making the pupil smaller.

Radial (dilator) muscles run like spokes of a wheel from pupil edge outward — when they contract, they pull the iris open, making the pupil larger.

Accommodation — Extended

Accommodation is the process by which the lens changes shape to focus on objects at different distances.

Focusing onCiliary musclesSuspensory ligamentsLens shapeFocal length
Near object Contract (ring gets smaller) Slacken (less tension) Fatter / more curved Short (converges light strongly)
Distant object Relax (ring gets larger) Taut (pulled tight) Thinner / less curved Long (converges light gently)
The key link: ciliary muscles contract → ligaments slacken → lens fattens

Many students reverse the ciliary muscle/ligament relationship. Remember: ciliary muscles form a ring. When the ring contracts it gets smaller, which reduces the diameter of the space inside — the suspensory ligaments attached to the lens go slack (no longer being pulled outward). With tension removed, the elastic lens springs back to its natural, fatter shape.

Rods and Cones — Extended

FeatureRodsCones
Light sensitivityVery sensitive — work in dim lightLess sensitive — need bright light
Colour vision?No — only detect light/darkYes — three types for red, green, blue
Visual acuityLow — many rods converge to one nerve fibreHigh — each cone has its own nerve fibre
DistributionMainly peripheral retinaConcentrated at fovea
PigmentRhodopsin (breaks down in light, regenerated in dark)Three different photopsins (red, green, blue)
MCQ · Topic 14.2Core

A person walks from a brightly lit room into a dark room. Which change occurs in the eye?

  • A. Circular iris muscles contract, pupil constricts
  • B. Radial iris muscles relax, pupil constricts
  • C. Radial iris muscles contract, pupil dilates
  • D. Ciliary muscles contract, lens becomes thinner
Answer: C. In dim/dark conditions, the radial (dilator) muscles of the iris contract. These muscles run outward from the pupil like spokes — contracting them pulls the iris outward, increasing the pupil diameter (dilation). This allows more light to enter the eye. Circular muscles relax. Ciliary muscles control accommodation (lens shape), not pupil size.
Paper 4 Style · Topic 14.2Extended

Describe how the lens changes to focus on a near object. Include the roles of the ciliary muscles, suspensory ligaments, and the lens itself. [4 marks]

Mark scheme
  • The ciliary muscles contract, reducing the diameter of the ciliary body ring [1 mark]
  • This causes the suspensory ligaments to slacken (less tension on the lens) [1 mark]
  • The elastic lens becomes fatter / more curved / more convex [1 mark]
  • The fatter lens has a shorter focal length and refracts light more strongly, converging it onto the retina for a near object [1 mark]
Exam Prep

Comprehensive Practice Questions

Mixed questions across Topics 14.1 and 14.2.

MCQ · Neurone typesCore

Which neurone carries impulses from the CNS to a muscle?

  • A. Sensory neurone
  • B. Relay neurone
  • C. Motor neurone
  • D. Receptor cell
Answer: C — Motor neurone. Motor neurones carry impulses FROM the CNS (brain or spinal cord) TO effectors (muscles or glands). Sensory neurones carry impulses from receptors to the CNS. Relay neurones are entirely within the CNS. A receptor cell detects stimuli but is not itself a neurone that transmits to muscles.
Paper 3 Style · Reflex arc + eyeCore

(a) State what is meant by a reflex action. [1 mark]
(b) Name the five components of a reflex arc in order. [2 marks]
(c) State the function of the fovea in the human eye. [2 marks]
(d) Explain why a person cannot see an object that falls on the blind spot of the retina. [2 marks]

Mark scheme
  • (a) A rapid, automatic, involuntary response to a stimulus that does not require conscious thought [1 mark]
  • (b) Receptor → sensory neurone → relay neurone → motor neurone → effector [1 mark for all five in correct order; allow 1 mark for 3–4 correct] [2 marks]
  • (c) The fovea contains a high concentration of cone cells [1 mark]; it is the region of highest visual acuity / sharpest colour vision [1 mark]
  • (d) The blind spot is where the optic nerve exits the eye [1 mark]; there are no photoreceptors (rods or cones) at this point, so light falling on it cannot generate a nerve impulse [1 mark]
Paper 4 Style · Synapse + myelinExtended

(a) Describe how an impulse crosses a synapse. [4 marks]
(b) Explain how the myelin sheath speeds up nerve impulse transmission. [2 marks]

(a) [4 marks]
  • Impulse arrives at the synaptic knob (pre-synaptic membrane) [1 mark]
  • Vesicles fuse with the pre-synaptic membrane, releasing neurotransmitter into the synaptic cleft [1 mark]
  • Neurotransmitter diffuses across the synaptic cleft [1 mark]
  • Neurotransmitter binds to specific receptors on the post-synaptic membrane, generating a new impulse in the next neurone [1 mark]
(b) [2 marks]
  • The myelin sheath is an insulating layer around the axon; the electrical impulse cannot pass through myelin [1 mark]
  • The impulse therefore jumps from node to node (nodes of Ranvier — gaps in the myelin sheath), covering greater distances per jump — this saltatory conduction is much faster than continuous conduction [1 mark]
Exam Prep

High-Frequency Mistakes — Topics 14.1 & 14.2

Topic 14A exam strategy

Highest-yield Core items: the three types of neurone with their functions and directions; the five-component reflex arc in order (receptor → sensory → relay → motor → effector); the definition of a reflex action; all eye structures with functions (particularly cornea, iris, lens, retina, fovea, blind spot). For Extended: the synaptic transmission sequence (four steps); myelin sheath and saltatory conduction; pupil reflex (circular vs radial muscles); accommodation mechanism (ciliary muscles → ligaments → lens shape — near and far); and rods vs cones comparison. Accommodation and the synapse are near-certain Paper 4 targets.

Cambridge International BiologySophriva · sophriva.com